In the fast-paced world of in-vitro diagnostics (IVD), access to biologically relevant and functionally validated proteins can make or break assay performance. At Denovo Biolabs, we recognize this need and supply researchers and diagnostic manufacturers with native C-Reactive Protein (CRP) and Hepatitis B Surface Antigen (HBsAg Ad/Ay subtypes), two critical biomarkers that continue to power infectious disease detection and inflammation-based assays across the globe.
CRP
A gold standard biomarker for inflammation
C-Reactive Protein (CRP) is a well-established marker for systemic inflammation, cardiovascular risk, and infection monitoring. Its clinical relevance spans multiple domains from acute infection detection to chronic inflammatory disease management.
At Denovo, our native CRP protein is:
- Purified from human plasma, ensuring native conformation
- Tested for ELISA and Lateral Flow Assay (LFA) compatibility
- Analytically sensitive in the ng/mL range, making it ideal for high-sensitivity platforms
- Free from cross-reactive contaminants for consistent, reproducible results
Whether you’re developing a high-sensitivity ELISA for cardiovascular diagnostics or a point-of-care LFA for sepsis monitoring, this native CRP ensures your results are both clinically reliable and assay-ready.
HBsAg Ad/Ay
Diagnostic backbone of Hepatitis B testing
Hepatitis B Surface Antigen (HBsAg) is a cornerstone in the screening and diagnosis of Hepatitis B virus (HBV). The Ad and Ay subtypes are the most prevalent in various regions and are critical for ensuring comprehensive detection in serological assays.
Denovo’s HBsAg Ad/Ay antigen is:
- Derived from HBV-positive plasma
- Fully validated for ELISA and LFA-based applications
- Sensitive to ng/mL concentration levels, enabling early-stage detection
- Recognized by a wide range of anti-HBs antibodies
This makes our HBsAg product ideal for screening assays, blood safety diagnostics, and disease surveillance kits, especially in resource-constrained geographies where early detection is essential.
Why native proteins are important?
While recombinant proteins dominate many assay formats today, native proteins retain:
- Authentic post-translational modifications
- Natural folding and glycosylation patterns
- Improved antibody recognition and binding affinity
For certain diagnostic applications especially those requiring clinical-grade sensitivity and specificity—native antigens and proteins remain the gold standard.
Designed for ELISA & LFA
Validated and ready to use
Both our native CRP and HBsAg Ad/Ay antigens have been rigorously validated for use in ELISA and Lateral Flow formats, the most commonly adopted assay types in clinical and field-based diagnostics. Our in-house quality controls ensure:
- High batch-to-batch consistency
- Minimal matrix interference
- Long-term stability for storage and shipping
Conclusion:
At Denovo Biolabs, we work behind the scenes to help diagnostic innovators build faster, better, and more accurate assays. Our native CRP and HBsAg Ad/Ay antigens are already supporting researchers, diagnostic startups, and established IVD players around the world.
If you are building the next generation of infection detection, inflammation monitoring, or viral screening tools, let’s collaborate.
📩 Get in touch to explore bulk availability, custom packaging, or validation support.