Recombinant Proteins
Recombinant Human Prostaglandin E Synthase, Microsomal (PTGES)
Product Description
Recombinant Human Prostaglandin E Synthase, Microsomal (PTGES), expressed in Escherichia coli (E. coli) and purified by standard chromatographic techniques.
Scientific Background
Microsomal prostagland in E synthase-1 (mPGES-1) is an enzyme that in humans is encoded by the PTGES gene. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis. Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson’s disease.
| Catalouge No. | RP2047 |
|---|---|
| Pack Size | 100 µg |
| Formulation Buffer | 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose. |
| Purity | > 90% pure as determined by Silver stained SDS-PAGE analysis. Molecular Weight: ~44KDa |
| Storage | Shipped at 2-8°C. Aliqote and Storet at-80C; Avoid repeated freeze/thaw cycles. |
| Regulatory | For research use only (RUO) |